Indian Journal of Allergy, Asthma and Immunology

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 31  |  Issue : 2  |  Page : 76--82

Factors influencing age of onset of wheezing among children with recurrent wheezing and the association of Vitamin D status with atopic manifestations


Bijay Kumar Meher1, Deepti Damayanty Pradhan2, S Pradeep1, Leena Das1, Siba Shankar Beriha1, Sumanta Panigrahi1 
1 Department of Pediatrics, Sardar Vallabhbhai Patel Post Graduate Institute of Paediatrics, SCB Medical College, Cuttack, India
2 Department of Pediatrics, KIMS, Bhubaneswar, Odisha, India

Correspondence Address:
Bijay Kumar Meher
C/455, Sector-6, CDA, Cuttack - 753 014, Odisha
India

Background: Onset of wheezing before 3 years of age is concerning due to its potential for the development of asthma. Different risk factors, atopic manifestations, and Vitamin D deficiency are attributed to it. Aims: The aim of this study is to assess the factors influencing the age of wheezing onset among children with early-onset recurrent wheezing and the association of Vitamin D status with different atopic manifestations. Subjects And Methods: This cross-sectional observational study included 141 children aged from 1 month to 14 years with recurrent wheezing. Onset of wheezing after 36 months was excluded from the study. Different risk factors and atopic manifestations were recorded, and Vitamin D levels were measured. Descriptive analysis, independent t-test, analysis of variance, and regression analysis were done using SPSS version 24.0. Results: Of 141 children, 65 (46.0%) had onset of wheezing at <1 year of age. Children with onset of wheezing <1 year had early age of presentation (29.38 ± 29.35 vs. 46.25 ± 27.77 months) were predominately male (52.1% vs. 47.9%) and had a low birth weight (2688.46 ± 608.84 vs. 2904.61 ± 510.96 g) and high Vitamin D level (22.01 ± 12.63 vs. 16.65 ± 9.05 ng/mL; P < 0.05). In the regression analysis, birth weight, family with >1 sibling, and atopic dermatitis had regression coefficients of 0.393 (P < 0.01), 4.525 (P < 0.01), and −2.970, respectively (P > 0.05). Conclusions: Children with onset of wheezing before 1 year were predominantly male and had a lower birth weight. Vitamin D deficiency does not hasten the onset of wheezing; however, a low birth weight and associated atopic dermatitis hasten the onset of wheezing, and being part of a family with >1 sibling delays onset.


How to cite this article:
Meher BK, Pradhan DD, Pradeep S, Das L, Beriha SS, Panigrahi S. Factors influencing age of onset of wheezing among children with recurrent wheezing and the association of Vitamin D status with atopic manifestations.Indian J Allergy Asthma Immunol 2017;31:76-82


How to cite this URL:
Meher BK, Pradhan DD, Pradeep S, Das L, Beriha SS, Panigrahi S. Factors influencing age of onset of wheezing among children with recurrent wheezing and the association of Vitamin D status with atopic manifestations. Indian J Allergy Asthma Immunol [serial online] 2017 [cited 2021 Oct 27 ];31:76-82
Available from: https://www.ijaai.in/article.asp?issn=0972-6691;year=2017;volume=31;issue=2;spage=76;epage=82;aulast=Meher;type=0