| RESEARCH ARTICLE |
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| Year : 2013 | Volume
: 27
| Issue : 1 | Page : 47-51 |
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Immunopathologic responses of silkmoth allergen on primary and secondary lymphoid organs of mice
Bada Venkatappa, Aluganti Chandrakala, Aswartha Harinatha Reddy, Gurujala Nageswari, Belaganti Chatrappa
Department of Microbiology, Immunology Division, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India
Correspondence Address:
Bada Venkatappa
Department of Microbioloogy, Immunology Division, Sri Krishnadevaraya University, Anantapur - 515 003, Andhra Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-6691.116612
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Silkmoth scales are allergens that cause several disabling hypersensitive lung diseases like asthma and allergic rhinitis in sericulture grainage industrial workers. Immunopathological responses of silkmoth allergen on primary and secondary lymphoid organs were studied in albino mice. Mice were immunized intraperitoneally and then subsequently challenged with silkmoth allergen intranasally. The mice were then evaluated for total serum IgE, eosinophil viability, and culturing of splenocytes in the presence of PHA, eosinophil peroxidase of bone marrow cells and histology of the thymus. The results indicate that the sensitized mice shows increased levels of IgE, decreased splenocyte viability and cell depletion in the thymus, and increased eosinophils in the lungs. The stimulated spleen showed a typical Th 2 pattern in all allergen sensitized animals. |
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