Indian Journal of Allergy, Asthma and Immunology

RESEARCH ARTICLE
Year
: 2013  |  Volume : 27  |  Issue : 1  |  Page : 47--51

Immunopathologic responses of silkmoth allergen on primary and secondary lymphoid organs of mice


Bada Venkatappa, Aluganti Chandrakala, Aswartha Harinatha Reddy, Gurujala Nageswari, Belaganti Chatrappa 
 Department of Microbiology, Immunology Division, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India

Correspondence Address:
Bada Venkatappa
Department of Microbioloogy, Immunology Division, Sri Krishnadevaraya University, Anantapur - 515 003, Andhra Pradesh
India

Silkmoth scales are allergens that cause several disabling hypersensitive lung diseases like asthma and allergic rhinitis in sericulture grainage industrial workers. Immunopathological responses of silkmoth allergen on primary and secondary lymphoid organs were studied in albino mice. Mice were immunized intraperitoneally and then subsequently challenged with silkmoth allergen intranasally. The mice were then evaluated for total serum IgE, eosinophil viability, and culturing of splenocytes in the presence of PHA, eosinophil peroxidase of bone marrow cells and histology of the thymus. The results indicate that the sensitized mice shows increased levels of IgE, decreased splenocyte viability and cell depletion in the thymus, and increased eosinophils in the lungs. The stimulated spleen showed a typical Th 2 pattern in all allergen sensitized animals.


How to cite this article:
Venkatappa B, Chandrakala A, Reddy AH, Nageswari G, Chatrappa B. Immunopathologic responses of silkmoth allergen on primary and secondary lymphoid organs of mice.Indian J Allergy Asthma Immunol 2013;27:47-51


How to cite this URL:
Venkatappa B, Chandrakala A, Reddy AH, Nageswari G, Chatrappa B. Immunopathologic responses of silkmoth allergen on primary and secondary lymphoid organs of mice. Indian J Allergy Asthma Immunol [serial online] 2013 [cited 2019 Dec 15 ];27:47-51
Available from: http://www.ijaai.in/article.asp?issn=0972-6691;year=2013;volume=27;issue=1;spage=47;epage=51;aulast=Venkatappa;type=0