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ORIGINAL ARTICLE
Year : 2016  |  Volume : 30  |  Issue : 2  |  Page : 91-94

A cross-sectional study of clinico-immunological profile of systemic lupus erythematosus patients in a tertiary care centre in Mangalore


Department of Microbiology, Father Muller Medical College, Mangalore, Karnataka, India

Correspondence Address:
Neethu Kishor
Department of Microbiology, Father Muller Medical College, Kankanady, Mangalore - 575 002, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-6691.195250

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Introduction: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, which occurs frequently in women, mainly at childbearing age. This disease can affect any organ system; its presentation and course over time are highly variable. It is characterized by autoantibody response to nuclear and cytoplasmic antigens. Inadequate data on its clinico-immunological profile are available. The present study focuses on reevaluating clinical and immunological manifestations and also the management of SLE patients. Materials and Methods: The study was carried out in a tertiary care hospital for 2 years, i.e., from June 2014 to May 2016. Patients of all age groups fulfilling revised American College of Rheumatology Criteria (1997) was included in this study. Baseline investigations were done, and autoantibody profiling was done using immunoblot strips coated with 14 different antigens. Results: Over a period of 2 years, 40 patients were studied. The majority (85%) was females, and most of the patients were of the age group 15-30 years. Fever was the most common clinical manifestation (55%), followed by arthritis (33%) and dermatological manifestations (25%). Antinuclear antibody profile showed autoantibodies against nucleosomes in 19 patients (48%), followed by nRNP in 18 (45%), dsDNA in 17 (43%), Ro in 16 (40%), ribosomal P in 16 (40%), Sm in 13 (33%), and histones in 13 (33%) patients. Most of the patients (45%) were treated with a combination of corticosteroid and antimalarial. Conclusion: Clinical manifestations can vary between fever, arthritis, and skin rash to severe systemic involvement. The disease is more common in females especially during the second and third decade of life. Autoantibody profiling aids in supporting diagnosis and antimalarials along with corticosteroids are mainstay of treatment.


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