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REVIEW ARTICLE
Year : 2016  |  Volume : 30  |  Issue : 1  |  Page : 4-11

Clinical correlation of oxidant-antioxidant balance and Vitamin D in asthmatic patients


1 Department of T.B. and Chest, Santosh Medical College, Ghaziabad, Uttar Pradesh, India
2 Department of Biochemistry, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India
3 Department of Biochemistry, Santosh Medical College, Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Brijendra Pratap Mishra
Department of Biochemistry, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-6691.187551

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Asthma is a chronic inflammatory lung disease that results in airflow limitation, hyperreactivity, and airway remodeling. There is strong evidence that an imbalance between the reducing and oxidizing systems lead more oxidative state in asthma. Endogenous and exogenous reactive oxygen species and reactive nitrogen species play a major role in the airway inflammation and cause of severe pathogenesis. Atmospheric pollution, dietary changes, changes in allergen load, improvements in health and hygiene, and lifestyle changes have all been proposed for asthma. It has been observed, poor antioxidant rich nutrition and lack of Vitamin D are also a common cause for pathogenesis of asthma. Vitamin D as lung immunomodulator and Vitamins A, C, E as antioxidants improves the complications of inflamed airflow in asthma. In this review study, we will summarize the current knowledge and discuss the current pharmacological strategies regarding the role of antioxidant activity and Vitamin D in favor to regulate and prognose to inflammatory asthma.


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