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ORIGINAL ARTICLE
Year : 2014  |  Volume : 28  |  Issue : 2  |  Page : 86-92

A prospective study of comparison of efficacy and safety between levocetirizine and olopatadine in chronic idiopathic urticaria


1 Department of Pharmacology, NIMS Medical College, Jaipur, India
2 Department of Pharmacology, J.L.N. Medical College, Ajmer, India
3 Department of Pharmacology, S.M.S. Medical College, Jaipur, Rajasthan, India
4 Department of Dermatology, S.M.S. Medical College, Jaipur, Rajasthan, India

Correspondence Address:
Dhirendra Kumar Mahawar
V.P.-Mohanpura, Tehsil-Bassi, Jaipur - 303 301, Rajasthan
India
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Source of Support: J. L. N. Medical College and Associated Hospital, Ajmer, Rajasthan, India, Conflict of Interest: None


DOI: 10.4103/0972-6691.140783

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Aims and Objective: The aim was to compare efficacy and safety of olopatadine with levocetirizine in patients of chronic idiopathic urticaria (CIU). Materials and Methods: This was a prospective, open, parallel, comparative randomized study. After assessing inclusion and exclusion criteria, patients were randomized and divided into two treatment groups: Group A (n = 77) received levocetirizine 5 mg once a day orally, and Group B (n = 77) received olopatadine 5 mg twice a day orally for 6 weeks. Patients were evaluated in terms of parameters under study that is, urticarial activity score (UAS), dermatological life quality index (DLQI), visual analog scale (VAS) (daytime sedation), and adverse drug reactions monitoring at every (2 weeks) visit. Statistical Analysis: We used the Student's t-test and the analysis of covariance for comparison of the results and the Chi-square test for comparison of incidence of adverse effects . Results: Both drugs reduced UAS significantly (P < 0.05) at all visits and olopatadine reduced UAS more than levocetirizine at 2 weeks (P < 0.05). Both drugs altered VAS at all visits significantly; however, inter-group differences were not significant. Each drug reduced DLQI score significantly. Levocetirizine reduced more DLQI than olopatadine, but the difference was not significant (P > 0.05). Olopatadine was associated with more side-effect profile, and most common side-effect was somnolence in both groups. Conclusion: Levocetirizine is a marginally superior drug as compared with olopatadine for long-term treatment of CIU in Indian population.


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