Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 123
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
CASE REPORT
Year : 2014  |  Volume : 28  |  Issue : 1  |  Page : 47-48

Successful allergen immunotherapy with horse dander allergy


Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, India

Date of Web Publication11-Jun-2014

Correspondence Address:
S. N. Gaur
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi - 110 007
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-6691.134225

Rights and Permissions
  Abstract 

Allergic disease induced by animal exposure is a well-known fact. Exposure to dander of pets such as cats and dogs can lead to allergic manifestations of allergic rhinitis, allergic asthma, and contact urticaria is a well-recognized fact. Allergy to horses can also present with all these symptoms as well as anaphylaxis in the subjects who are previously sensitized. Horse allergy is induced by exposure to the major horse allergens Equ 1 through five with the level of exposure determining the level of severity. Greatest risk of anaphylaxis occurs in those sensitized patients who have large amounts of animal allergen exposure, with maximum chances with animal bite as it exposes the sensitized persons to large quantities of the animal allergen that resides in the saliva. Horse allergy may be successfully treated with allergen specific immunotherapy.

Keywords: Allergen immunotherapy, anaphylaxis, horse dander


How to cite this article:
Gaur SN, Bhati G. Successful allergen immunotherapy with horse dander allergy. Indian J Allergy Asthma Immunol 2014;28:47-8

How to cite this URL:
Gaur SN, Bhati G. Successful allergen immunotherapy with horse dander allergy. Indian J Allergy Asthma Immunol [serial online] 2014 [cited 2019 Aug 19];28:47-8. Available from: http://www.ijaai.in/text.asp?2014/28/1/47/134225


  Introduction Top


Allergic diseases caused by animals are not uncommon. Allergy to pets, such as cats and dogs, horses can lead to significant morbidities in children. Allergies to pets can manifest as asthma, urticaria, angioedema, contact dermatitis and anaphylaxis. At many places in developing countries horses are still used for various works, including transportation whereas in developed countries, horses are widely owned and used for recreational activities. Horses have been recognized as an important source of allergens for people who regularly work with horses, either professionally or for recreational purposes. Despite the presence of horses in a variety of recreational, sporting, and work environments, there are only a few reports of anaphylactic episodes resulting from horse allergy.


  Case report Top


An 18-year-old boy, presented with episodes of acute breathlessness, wheeze and nasal symptoms, within 10 min of coming in contact with horses. Prior to presentation at our institute, the boy had an episode of nausea, vomiting, diarrhea and breathlessness, followed by drowsiness during horse riding. During the present episode on examination he had pulse rate of 110/min, blood pressure 80/50 mm Hg and an axillary temperature of 36.3°C. Lung auscultation revealed wheeze throughout all lung fields. He was diagnosed to be in anaphylaxis and was treated with subcutaneous injection adrenaline (1:1000), intravenous hydrocortisone, antihistamines, and physiological saline. The patient recovered and was subsequently discharged 24 h later. After recovered fully from systemic reactions, he was brought at Department of Pulmonary Medicine, University of Delhi, Delhi (India).

The detailed history of a patient revealed several such as episodes of anaphylaxis and hospital admissions on coming in contact with horse in the past as well, out of which three episodes were within a span of 3 months. The skin prick test was done, which tested strongly positive +++ only with horse dander allergen. It was done using different concentrations (0.001, 0.01 and 0.1 μg/ml) of horse dander allergen supplied by All Cure Pharma. He was then started with subcutaneous specific allergen immunotherapy (SCIT). Even on treatment the boy faced mild symptoms during the 1 st year. After being given the immunotherapy in the maintenance dose for 1.5 years (up to 2004), he never had anaphylaxis even on coming in contact or riding the horses until now although he discontinued SCIT after 1.5 years on his own due to sufficient improvement.


  Discussion Top


Horses are known from the ancient times to be the animal of use for daily purposes and work. In the modern world, horses are being used for recreational purposes. Allergic manifestations such as asthma and anaphylaxis has been connected with a number of animals, including cats, dogs, rats, mice, cows, and horses. [1] A correlation between the exposure of farm animals at early childhood and allergic manifestation has been made by various studies done in Europe. The studies indicate that early exposure to farm animals leads to a protective effect against animal induced allergy and asthma. [2],[3],[4] also exposure to animals at homes during the 1 st year of life has a similar protective effect, by development of immune response by immunoglobulin (IgG) directed against animal dander. [5]

Horses have also proven to be one of the important and significant allergen sources among all the mammalian allergens. Horse dander, hair, and skin scrapings can lead to manifestations of allergic response. In 1950s, the first allergic reactions to horse serum on therapeutic injection were described and thus horse serum albumin was reported as the first known horse allergen. [6] In the 1970s, various dander derived allergens were described, which were designated as Ag 6, Ag 9, and Ag 11. Subjects with allergy to horses were found to have specific IgE against these antigens. [7] Horse allergens are mainly protein in nature with molecular mass ranging between 10 kDa and 75 kDa. [7]

Horse allergens are of four types that have been purified to homogenicity until date namely Equ c1, Equ c2, Equ c3 and Equ c4. Equ c1 is a major hair dandruff protein synthesized in liver and in the sublingual and submaxillary salivary glands whereas Equ c2 and Equ c3 were isolated from horse sweat. Purification of Equ c4 has led to a new allergen from horse dander named as Equ c5 which has now been identified and characterized. [8]

Horse allergy occurring among handlers of horses is mainly characterized by rhinitis, conjunctivitis, asthma, urticaria and at times anaphylaxis. Although allergen avoidance has been crucial for management of allergic manifestations, pharmacotherapy with injectable epinephrine, oral antihistamine for the management of the anaphylaxis is recommended. A proper diagnosis of horse allergy can be made based on skin prick test, which is both simple and inexpensive. Allergen immunotherapy may be the treatment of choice in cases of animal allergy in cases where allergen avoidance is not possible. [9] Allergen immunotherapy against horse allergy has been proved both safe and efficacious in patients with allergic symptoms of asthma and rhino-conjuctivitis with or without cutaneous symptoms. [10]

In this case, the boy tested strongly positive +++ for horse dander and had anaphylactic reactions in the past as well.


  Conclusion Top


It is concluded that physicians should be aware of the anaphylactic reaction due to exposure to horse dander and specific allergen immunotherapy with horse dander (whole body extract) is effective and lifesaving.

 
  References Top

1.Roberts G, Peckitt C, Northstone K, Strachan D, Lack G, Henderson J, et al. Relationship between aeroallergen and food allergen sensitization in childhood. Clin Exp Allergy 2005;35:933-40.  Back to cited text no. 1
    
2.Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000;30:194-200.  Back to cited text no. 2
    
3.Kilpeläinen M, Terho EO, Helenius H, Koskenvuo M. Farm environment in childhood prevents the development of allergies. Clin Exp Allergy 2000;30:201-8.  Back to cited text no. 3
    
4.Ernst P, Cormier Y. Relative scarcity of asthma and atopy among rural adolescents raised on a farm. Am J Respir Crit Care Med 2000;161:1563-6.  Back to cited text no. 4
    
5.Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: A population-based cross-sectional study. Lancet 2001;357:752-6.  Back to cited text no. 5
    
6.Gregoire C, Rosinski-Chupin I, Rabillon J, Alzari PM, David B, Dandeu JP. cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily. J Biol Chem 1996;271:32951-9.  Back to cited text no. 6
    
7.Løowenstein H, Markussen B, Weeke B. Isolation and partial characterization of three major allergens of horse hair and dandruff. Int Arch Allergy Appl Immunol 1976;51:48-67.  Back to cited text no. 7
    
8.Goubran Botros H, Gregoire C, Rabillon J, David B, Dandeu JP. Cross-antigenicity of horse serum albumin with dog and cat albumins: Study of three short peptides with significant inhibitory activity towards specific human IgE and IgG antibodies. Immunology 1996;88:340-7.  Back to cited text no. 8
    
9.Nelson HS. Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol 2005;115:676-84.  Back to cited text no. 9
[PUBMED]    
10.Fernández-Távora L, Rico P, Martín S. Clinical experience with specific immunotherapy to horse dander. J Investig Allergol Clin Immunol 2002;12:29-33.  Back to cited text no. 10
    




 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case report
Discussion
Conclusion
References

 Article Access Statistics
    Viewed1251    
    Printed46    
    Emailed0    
    PDF Downloaded101    
    Comments [Add]    

Recommend this journal