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ORIGINAL ARTICLE
Year : 2014  |  Volume : 28  |  Issue : 1  |  Page : 27-34

Use of beclomethasone/budesonide and formoterol adjustable dose as single maintenance and rescue therapy in the management of bronchial asthma


Department of Pulmonary Medicine, T. N. Medical College and B. Y. L. Nair Ch. Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Ketaki Satish Barve
Department of Pulmonary Medicine, T. N. Medical College and B. Y. L. Nair Ch. Hospital, Mumbai Central, Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-6691.134218

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Aims: The aim of the following study is to determine the efficacy of single maintenance and rescue therapy (SMART) with adjustable dosing in management of persistent bronchial asthma. Settings and Design: It was a follow-up, prospective observational study over a period of 1 year in the pulmonary medicine department of a tertiary hospital. Subjects and Methods: Patients with newly diagnosed persistent bronchial asthma were started on a single inhaler containing budesonide/formoterol in a combination of 100 mcg/6 mcg in a dose of 4 puffs twice daily with as needed extra puffs (up to maximum 12 puffs/day) and were monitored for the subjective and objective control of asthma with parameters such as asthma control test score, forced expiratory volume in 1 s and peak expiratory flow rate in total 4 follow-up visits at 1 month, 3 months, 6 months and 1 year with step ping up or stepping down of the therapy according to the level of control of asthma. Statistical Analysis Used: The data was statistically analyzed by t-test using SPSS 14 software. Results: Guideline-defined asthma control could be achieved in 34 of the 40 patients and they could be successfully stepped down. Only 3 out of the 40 patients had acute exacerbations all of which were mild. They were managed by stepping up of the therapy. In another three patients stepping down was not possible due to persistence of partially controlled asthma. There was overall improved compliance on the part of the patients. Conclusions: SMART therapy is effective in the treatment of bronchial asthma in our kind of set-up. Only in future, similar studies need to be done with a larger sample size.


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