Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 174
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
RESEARCH ARTICLE
Year : 2013  |  Volume : 27  |  Issue : 1  |  Page : 47-51

Immunopathologic responses of silkmoth allergen on primary and secondary lymphoid organs of mice


Department of Microbiology, Immunology Division, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India

Correspondence Address:
Bada Venkatappa
Department of Microbioloogy, Immunology Division, Sri Krishnadevaraya University, Anantapur - 515 003, Andhra Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-6691.116612

Rights and Permissions

Silkmoth scales are allergens that cause several disabling hypersensitive lung diseases like asthma and allergic rhinitis in sericulture grainage industrial workers. Immunopathological responses of silkmoth allergen on primary and secondary lymphoid organs were studied in albino mice. Mice were immunized intraperitoneally and then subsequently challenged with silkmoth allergen intranasally. The mice were then evaluated for total serum IgE, eosinophil viability, and culturing of splenocytes in the presence of PHA, eosinophil peroxidase of bone marrow cells and histology of the thymus. The results indicate that the sensitized mice shows increased levels of IgE, decreased splenocyte viability and cell depletion in the thymus, and increased eosinophils in the lungs. The stimulated spleen showed a typical Th 2 pattern in all allergen sensitized animals.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1498    
    Printed55    
    Emailed0    
    PDF Downloaded101    
    Comments [Add]    

Recommend this journal